Rx ointment only zovirax acyclovir ointment Product Information Product Type human prescription zovirax drug label Item Code (Source) NDC: Route of zovirax Administration topical ointment DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of ointment Strength Strength acyclovir (acyclovir) acyclovir 50 mg in ointment 1 g Inactive Ingredients Ingredient Name Strength. If zovirax you zovirax cream are currently a resident of zovirax the zovirax United States, please reach out at and ointment let us know. To protect young children ointment from poisoning, always lock safety caps ointment and immediately place the ointment medication in a safe location one that is zovirax up and away and out of zovirax their sight and reach. The chemical name of acyclovir is it has the ointment following structural formula: Indications Dosage, indications, zovirax ( acyclovir ointment 5 is indicated in the zovirax management of initial genital herpes zovirax and in limited non-life-threatening mucocutaneous. Generic name: acyclovir ointment - topical (ay-SYE-kloe-vir). The links are provided only as citations and aids to zovirax help you locate and identify other Internet resources that may zovirax be of interest. Local pharmacies serving every community accept Blink, zovirax over the counter including Walmart, Albertsons, Kroger, Kmart and many more. Rub the ointment cream zovirax into the skin until it disappears. Drug zovirax interactions Clinical experience zovirax has identified no interactions resulting from topical or systemic administration zovirax of other drugs concomitantly with zovirax Ointment. If you experience any of these symptoms, call your zovirax cream ointment doctor zovirax immediately: hives rash itching difficulty breathing or swallowing swelling of the face, throat, lips, eyes, hands, feet, ankles, or lower legs hoarseness, topical acyclovir may cause other side effects. Scroll down for Important Safety Information. Acyclovir zovirax pills cream is used to treat cold sores (fever blisters; blisters that are caused by a virus called herpes simplex) on the face zovirax or lips. Otherwise, call a poison control center right away. Drug Resistance: Resistance of HSV and VZV to acyclovir can result from qualitative and quantitative changes ointment in the viral TK and/or DNA polymerase. It is important to keep all medication out of sight and reach of children as many containers (such as weekly ointment pill minders and those for eye drops, creams, patches, zovirax cream and inhalers) are not child-resistant and young children can open them easily. Unless your doctor tells you otherwise, ointment continue your normal diet. Do not apply extra cream or ointment to make up for a missed dose. In vitro, acyclovir triphosphate stops replication of herpes viral DNA. Acyclovir is an antiviral drug. Contraindications zovirax Ointment ointment 5 is contraindicated in patients who develop hypersensitivity to the components of the formulation. Talk to your pharmacist for more fore using this medication, tell your doctor or pharmacist your medical fore having surgery, tell your doctor or dentist about all the products you use (including ointment prescription drugs, nonprescription drugs, and herbal products). If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. This is accomplished in 3 ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNA chain, ointment and 3) inactivation of the viral DNA polymerase. It works by stopping the spread of the herpes virus in the body. Tell your doctor if zovirax you have or have ever had any condition that affects your immune system such zovirax as human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (aids). Warnings, zovirax Ointment 5 is intended for cutaneous use only and should ointment not be used in the eye. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Clinical Trials In clinical trials of initial genital herpes infections, zovirax Ointment 5 has shown a decrease in healing time and, in some cases, a decrease in duration of viral shedding and duration of pain. Try not to touch the cold sore. Pediatric Use: Safety and effectiveness in pediatric patients have not been established. Apply enough ointment to cover all sores, usually every 3 hours, 6 times a day, or as directed by your doctor. Use ointment topical acyclovir exactly as directed. However, the small size of the registry is insufficient to evaluate the risk for less common defects or to permit reliable or definitive conclusions regarding the safety of acyclovir in pregnant women ointment and their developing fetuses. Overdosage Contraindications overdose Overdosage by topical application of zovirax Ointment 5 is unlikely because of limited transcutaneous absorption (see zovirax clinical pharmacology ). In one of these studies, which included 16 inpatients, the complete ointment or its zovirax vehicle were randomly administered in a dose of 1-cm strips (25 mg acyclovir) 4 times a day for 7 days to an intact skin surface area.5 square inches. Although clinically significant viral resistance associated with the use of Zovirax Ointment 5 has not been observed, this possibility exists. Using plaque-reduction zovirax assays, the IC50 against HSV isolates ranges from.02.5 mcg/mL for HSV-1 and from.01.9 mcg/mL for HSV-2. Take the Genital Herpes Quiz, drug Description, zovirax (acyclovir) Ointment. Do not flush medications ointment down the toilet or pour them into a drain unless instructed zovirax to. Discuss the risks and benefits with your is unknown if this medication passes into breast milk. Acyclovir cream is usually applied five times a day for 4 days. Use zovirax Cream only on your affected skin. Nursing Mothers It is not known whether topically applied acyclovir is excreted in breast milk. After oral administration zovirax of zovirax, acyclovir concentrations have been documented in breast milk in 2 women and ranged from.6.1 zovirax ointment times the corresponding plasma levels. Acyclovir cream should only be applied to skin where a cold sore ointment has formed or seems likely to form. Zovirax (acyclovir) Ointment 5 is indicated in the management of initial genital herpes and in limited nonlifethreatening mucocutaneous HSV infections in immunocompromised patients. It is best to begin using acyclovir ointment as soon as possible after you experience the first symptoms of infection. Acyclovir also demonstrates activity against the Oka vaccine strain of VZV with a mean IC50.35 mcg/mL. Cold sore outbreaks can be caused by many factors such as stress, hormonal changes (such as pregnancy, menstrual period injury/surgery on the mouth (such as dental work zovirax tiredness, sunlight, cold weather, or fever/cold/ flu. Before using topical acyclovir, tell your doctor and pharmacist if you are allergic to acyclovir, valacyclovir (Valtrex any other medications, or any of the ingredients in acyclovir cream or ointment. Do not use more or less of it or use it more often than prescribed by your doctor. Consult your doctor or pharmacist for more details. Avoid close physical contact with others (such as kissing) during an outbreak until the cold sores have completely healed. Wear loose-fitting clothing over your herpes sores to keep from irritating them. Therapy should be initiated as early as possible following onset of signs and symptoms. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Apply enough ointment to cover all of your sores. Two clinical pharmacology studies were performed with zovirax Ointment 5 in immunocompromised adults at risk of developing mucocutaneous Herpes simplex virus infections or with localized varicella-zoster infections. Drug Interactions: Clinical experience has identified no interactions resulting from topical or systemic administration of other drugs concomitantly with Zovirax Ointment. Keep all medications away from children and not flush medications down the toilet or pour them into a drain unless instructed to. Sexually Transmitted Diseases (STDs) Slideshow Pictures Image Collection: Picture of Genital Warts (HPV) Take the Genital Herpes Quiz drug interactions: Drug interactions may change how your medications work or increase your risk for serious side effects. The other study included 11 patients with localized varicella-zoster infections. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. How is Zovirax Ointment Supplied Each gram of Zovirax Ointment 5 contains 50 mg acyclovir in a polyethylene glycol base. Each gram of zovirax Ointment 5 contains 50 mg of acyclovir in a polyethylene glycol (PEG) base. Tell your doctor if any of these symptoms are severe or do not go away: dry or cracked lips flaky, peeling, or dry skin burning or stinging skin redness, swelling, or irritation in the place where you applied the medication. You can spread genital herpes even if you do not have symptoms. If you become pregnant while using acyclovir, call your doctor. The pka's of acyclovir are.27 and.25. Side Effects Drug Interactions, sIDE effects, in the controlled zovirax clinical trials, mild pain (including transient burning and stinging) was reported by about 30 of patients in both the active and placebo arms; treatment was discontinued in 2 of these patients. Your zovirax dosage doctor may need to change the doses of your medications or monitor you carefully for side effects. Stop paying too much for your prescriptions. Therefore, systemic absorption of acyclovir after topical application is minimal. Carcinogenesis, Mutagenesis, Impairment Of Fertility Systemic exposure following topical administration of acyclovir is minimal. Other antiviral medications taken by mouth may be more effective in treating these conditions. Many people using this medication do not have serious side effects. Topical acyclovir may cause side effects. Zovirax Cream is most effective when used early, at the start of a cold sore. Geriatric Use Clinical studies of zovirax Ointment did not include sufficient numbers zovirax of subjects aged 65 and over to determine whether they respond zovirax differently from younger subjects. Consult your pharmacist or local waste disposal company. Clinical Trials, in clinical trials of initial genital herpes infections, Zovirax Ointment 5 has shown a decrease in healing time and, in some cases, a decrease in duration of viral shedding and duration of pain. Most independent pharmacies also accept Blink. Acyclovir is in a class of antiviral medications called synthetic ointment nucleoside analogues. Systemic absorption of acyclovir after topical administration is minimal (see clinical pharmacology ). Data are insufficient to support an estimate of their incidence or to establish causation. Using plaque-reduction assays, the IC50 against herpes simplex virus isolates ranges from.02.5 mcg/mL for HSV-1 and from.01.9 mcg/mL for HSV-2. For best results, zovirax apply the cream at the first sign of a cold sore (such as tingling, redness, bump, or itch). Instead, the best way to dispose of your medication is through a medicine take-back program. Systemic exposure following topical administration is minimal. Valeant Pharmaceuticals North America zovirax LLC Rev. It is supplied as follows: 30 g tubes NDC Store at 15 to 25C (59 to 77F) zovirax in a dry place. Distributed by Valeant Pharmaceuticals North America LLC, Bridgewater, NJ 08807. Antiviral Activities The quantitative relationship between the in vitro susceptibility of herpes viruses to antivirals and the clinical response to therapy has not been established in humans, and virus sensitivity testing has not been standardized. The IC50 for acyclovir against most laboratory strains and clinical isolates of VZV ranges from.12.8 mcg/mL. HOW supplied, each gram of, zovirax Ointment 5 contains 50 mg acyclovir in a polyethylene glycol base.
Clinical isolate of dosage herpes simplex dosage virus type 2 that induces a thymidine kinase with altered substrate specificity. Virology The quantitative relationship between the dosage in dosage vitro susceptibility of herpes simplex virus (HSV) and varicella-zoster viruses (VZV) to acyclovir and the clinical response to therapy has not zovirax been established in man, and virus sensitivity testing has not been standardized. This restriction requires that specific clinical criteria be met prior to the approval of the prescription. Zovirax (acyclovir a synthetic acyclic purine nucleoside analog, is a substrate with a high degree of specificity for herpes simplex and varicella -zoster specified thymidine kinase. Double-blind, placebo-controlled trial comparing long-term suppressive with short-term oral acyclovir therapy for management of recurrent genital herpes. It should be emphasized that the alterations in the nails appeared to be related to the transient toxicosis induced by dosage dose levels of 50 and 150 mg/kg/day zovirax tested during the first two weeks of the study and. In experiments in mice designed to test whether acyclovir would potentiate the immunosuppressive effect of azathioprine on antibody formation, it was found that the effects of the two drugs were zovirax no more than additive. Thus, 5 mg/kg was clearly a no effect dose level and 20 mg/kg caused only minimal decreases in body weight gain. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy. Female mice given 150 and 450 mg/kg acyclovir survived dosage significantly zovirax longer than control female mice; survival of treated males was comparable to survival of control males. Characterization of a DNA polymerase mutant of herpes simplex virus from a severely immunocompromised patient receiving acyclovir. What are the side effects of acyclovir? Symptoms of genital herpes. Influence of hemodialysis on acyclovir pharmacokinetics in patients with chronic renal failure. Herpes simplex and varicella-zoster specified thymidine kinase transform acyclovir to its monophosphate which is then transformed by a number of cellular enzymes to acyclovir diphosphate and acyclovir triphosphate. Acyclovir is a poor substrate for host cell-specified thymidine kinase. Concentrations of acyclovir were detected in plasma and amniotic fluid samples, as zovirax well as in homogenates of fetal tissues. In summary, the quantitative relationship between the in vitro susceptibility of HSV and VZV to acyclovir and the clinical response to therapy has not been clearly established in man. Offspring viability and development were also evaluated. Acyclovir treatment of varicella in otherwise healthy adolescents. Intermittent Therapy: 200 mg every 4 hours, 5 times daily for 5 days. Isolation and characterization of acyclovir-resistant mutants of herpes simplex virus. No effects attributable to the administration of acyclovir were noted in comparisons of maternal body weight values, appearance and behaviour, survival rates, pregnancy rates, or implantation efficiencies. Eye examinations and light microscopy did not reveal adverse effects on ocular development. Related Disease Conditions Chickenpox (Varicella) Chickenpox (chicken dosage pox) is a contagious childhood disease zovirax caused by the varicella-zoster virus. Acyclovir suppression of frequently recurring genital herpes. Marlowe S, Douglas J, Corey L, Schnipper L, Crumpacker. Jama 1988; 260(2 201-206. Acyclovir, at concentrations.5 and 125 g/mL for a 48-hour exposure, did not induce any chromosome aberrations in cultured human lymphocytes in the absence of exogenous metabolic activation. Prolonged dosage acyclovir treatment of highly immunocompromised patients with acquired immunodeficiency syndrome and severe VZV may lead to the appearance of resistant virus.
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